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Gulati A, Choudhuri R, Gupta A, Singh S, Ali SN, Sidhu GK, Haque PD, Rahate P, Bothra AR, Singh GP, Maheshwari S. A multicentric, randomized, controlled phase III study of centhaquine (Lyfaquin®) as a resuscitative agent in hypovolemic shock patients. medRxiv. 2021 June 01 |
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Gulati A, Jain D, Agrawal NR, Rahate P, Choudhuri R, Das S, Dhibar DP, Prabhu M, Haveri S, Agarwal R, Lavhale MS. Resuscitative Effect of Centhaquine (Lyfaquin®) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial. Adv Ther. 2021 May 10. |
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Gulati A, Choudhuri R, Gupta A, Singh S, Ali SN, Sidhu GK, Haque PD, Rahate P, Bothra AR, Singh GP, Maheshwari S. A multicentric, randomized, controlled phase III study of centhaquine (Lyfaquin®) as a resuscitative agent in hypovolemic shock patients. medRxiv. 2020 Jan 1 |
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Gulati A, Lavhale M, Giri R, Andurkar S, Xanthos T, Gras J, Chopra S, Thakare R, Dasgupta A, Zafar MU, Badimon JJ. Centhaquine citrate. Alpha2B-Adrenoceptor ligand, Resuscitative agent for hypovolemic shock. Drugs Fut. 2020;45(3):153-63 |
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Gulati, A., D. Jain, N. R. Agrawal, S. Das, R. Chowdhuri, M. Prabhu, S. Haveri, R. Agarwal and M. S. Lavhale (2018). "Clinical Results Indicating Effectiveness of PMZ-2010 (Centhaquin) as a Novel Resuscitative Agent for Hypovolemic Shock." Circulation 138: A13092. |
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Gulati, A., D. Jain, N. R. Agrawal, P. Rahate, S. Das, R. Chowdhuri, D. Dhibar, M. Prabhu, S. Haveri, R. Agarwal and M. S. Lavhale (2018). "Clinical Phase II Results of PMZ-2010 (Centhaquin) As A Resuscitative Agent for Hypovolemic Shock." Critical Care Medicine 147(1): 23. |
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Gulati A, Jain D, Agrawal N, Rahate P, Das S, Chowdhuri R, Prabhu M, Haveri S, Dhibar D, Lavhale M. 1732: A PHASE II MULTICENTRIC RANDOMIZED CONTROLLED STUDY OF CENTHAQUINE IN HEMORRHAGIC SHOCK PATIENTS. Critical Care Medicine. 2020 Jan 1;48(1):840. |
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Gulati A, Jain D, Agrawal N, Rahate P, Das S, Chowdhuri R, Dhibar D, Prabhu M, Haveri S, Agarwal R, Lavhale M. 23: CLINICAL PHASE II RESULTS OF PMZ-2010 (CENTHAQUIN) AS A RESUSCITATIVE AGENT FOR HYPOVOLEMIC SHOCK. Read Online: Critical Care Medicine| Society of Critical Care Medicine. 2019 Jan 1;47(1):12. |
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Gulati A, Jain D, Agrawal NR, Das S, Chowdhuri R, Prabhu M, Haveri S, Agarwal R, Lavhale MS. Clinical Results Indicating Effectiveness of PMZ-2010 (Centhaquin) as a Novel Resuscitative Agent for Hypovolemic Shock. Circulation. 2018 Nov 6;138(Suppl_1):A13092- |
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Gulati, A., Goyal, A. O., and Lavhale, M. S. (2016) Human Pharmacokinetics of Centhaquin Citrate, a Novel Resuscitative Agent. Circulation 134:A16607 |
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O'Donnell, J. N., O'Donnell, E. P., Kumar, E. J., Lavhale, M. S., Andurkar, S. V., Gulati, A., and Scheetz, M. H. (2016) Pharmacokinetics of centhaquin citrate in a dog model. J Pharm Pharmacol 68, 803-809 |
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O'Donnell, J. N., Gulati, A., Lavhale, M. S., Sharma, S. S., Patel, A. J., Rhodes, N. J., and Scheetz, M. H. (2016) Pharmacokinetics of centhaquin citrate in a rat model. J Pharm Pharmacol 68, 56-62 |
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Gulati, A., Zhang, Z., and Arshad, K. (2011) Centhaquin Decreases the Requirement of Norepinephrine, Maintains Blood Pressure and Improves Survival Following Resuscitation of Hemorrhaged Rats. Crit Care Med 39, 114 |
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Gulati, A., Pais, G., Mulloy, N., and Zhang, Z. (2013) Effect of Centhaquin Resuscitation on Coagulation in a Rabbit Model of Uncontrolled Hemorrhagic Shock. Clin Pharmacol in Drug Develop 1710539 |
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Pais, G., and Gulati, A. (2012) Effect of Centhaquin on the Coagulation cascade using Thromboelastography (TEG). Crit Care Med 40, 181 |
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Kontouli, Z., Staikou, C., Iacovidou, N., Mamais, I., Kouskouni, E., Papalois, A., Papapanagiotou, P., Gulati, A., Chalkias, A., and Xanthos, T. (2018) Resuscitation with centhaquin and 6% hydroxyethyl starch 130/0.4 improves survival in a swine model of hemorrhagic shock: a randomized experimental study. Eur J Trauma Emerg Surg |
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Briyal, S., Gandhakwala, R., Khan, M., Lavhale, M. S., and Gulati, A. (2018) Alterations in endothelin receptors following hemorrhage and resuscitation by centhaquin. Physiol Res 67, S199-S214 |
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Papapanagiotou, P., Xanthos, T., Gulati, A., Chalkias, A., Papalois, A., Kontouli, Z., Alegakis, A., and Iacovidou, N. (2016) Centhaquin improves survival in a swine model of hemorrhagic shock. J Surg Res 200, 227-235 |
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Gulati A, Zhang Z, Arshad K. 414: CENTHAQUIN DECREASES THE REQUIREMENT OF NOREPINEPHRINE, MAINTAINS BLOOD PRESSURE AND IMPROVES SURVIVAL FOLLOWING RESUSCITATION OF HEMORRHAGED RATS. Critical Care Medicine. 2011 Dec 1;39(12):114. |
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Leonard, M., Zhang, Z., Briyal, S., Pais, G., Patel, S., and Gulati, A. (2016) Centhaquin Citrate Improves Cerebral Blood Flow and Reduces Oxidative Stress Following Hemorrhagic Shock in Rats. Circulation 134:A16059 |
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Gulati, A. (2016) Vascular Endothelium and Hypovolemic Shock. Curr Vasc Pharmacol 14, 187-195 |
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Goyal, A. O., Lavhale, M. S., and Gulati, A. (2015) Safety and Efficacy of Centhaquin as a Novel Resuscitative Agent for Hypovolemic Shock. Circulation 132:A17521 |
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Reniguntala, M. S., Lavhale, M. S., Andurkar, S. V., and Gulati, A. (2015) Synthesis and characterization of centhaquin and its citrate salt and a comparative evaluation of their cardiovascular actions. Drug Res (Stuttg) 65, 184-191 |
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Gulati, A., and Lavhale, M. (2014) Repositioning of Centhaquin as a Novel Resuscitative Agent. Basic Clin Pharmacol 115, 43-43 |
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Lavhale, M. S., Havalad, S., and Gulati, A. (2013) Resuscitative effect of centhaquin after hemorrhagic shock in rats. J Surg Res 179, 115-124 |
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Gulati, A., Mulloy, N., Zhang, Z., and Pais, G. (2013) Resuscitative efficacy of centhaquin in a rabbit model of uncontrolled hemorrhagic shock. Crit Care Med 534 |
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Gulati, A., Zhang, Z., Murphy, A., and Lavhale, M. S. (2013) Efficacy of centhaquin as a small volume resuscitative agent in severely hemorrhaged rats. Am J Emerg Med 31, 1315-1321 |
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Lavhale, M. S., and Gulati, A. (2012) Effect of Centhaquin resuscitation on cardiovascular functions and plasma cytokines of hemorrhaged rats. Clin Pharmacol in Drug Develop 1, 215 |
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Lavhale, M. S., and Gulati, A. (2012) Centhaquin resuscitation improves survival of hemorrhaged rats. Indian J Pharmacol 44, S80 |
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Gulati, A., Voshtina, E., Zhang, Z., and Murphy, M. (2012) Alpha adrenergic receptors mediate resuscitative effect of Centhaquin in hemorrhaged rats. Crit Care Med 40(12), 587 |
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Gulati, A., Lavhale, M. S., Garcia, D. J., and Havalad, S. (2012) Centhaquin improves resuscitative effect of hypertonic saline in hemorrhaged rats. J Surg Res 178, 415-423 |
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Gulati, A. (2012) Pharmacology and toxicology of centhaquin: A resuscitative agent. The 32nd Annual Conference of Society of Toxicology (STOX), CSIR-Indian Institute of Toxicology Research, Lucknow. |
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Briyal, S., Lavhale, M. S., and Gulati, A. (2012) Repeated administration of centhaquin to pregnant rats did not affect postnatal development and expression of endothelin receptors in the brain, heart or kidney of pups. Arzneimittelforschung 62, 670-676 |
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Tolentino, S., Havalad, S., Gulati, A., and Lavhale, M. (2011) Role of Centhaquin in the Resuscitation of Hemorrhagic Shock. Chest 140, 318A |
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Gulati, A., Lavhale, M. S., and Havalad, S. (2011) Role of centhaquin in the resuscitation of hemorrhagic shock. J Clin Pharmacol 51, 1349-1349 |
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Gulati, A., Hussain, G., and Srimal, R. C. (1991) Effect of repeated administration of centhaquin, a centrally acting hypotensive drug, on adrenergic, cholinergic (muscarinic), dopaminergic, and serotonergic receptors in brain-regions of rat. Drug Develop Res 23, 307-323 |
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Srimal, R. C., Gulati, K., Nityanand, S., and Dhawan, B. N. (1990) Pharmacological studies on 2-(2-(4-(3-methylphenyl)-1-piperazinyl)ethyl) quinoline (centhaquin). I. Hypotensive activity. Pharmacol Res 22, 319-329 |
